Orthanilic acid-promoted reverse turn formation in peptides.
نویسندگان
چکیده
Orthanilic acid (2-aminobenzenesulfonic acid, (S)Ant), an aromatic β-amino acid, has been shown to be highly useful in inducing a folded conformation in peptides. When incorporated into peptide sequences (Xaa-(S)Ant-Yaa), this rigid aromatic β-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.
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عنوان ژورنال:
- Chemical communications
دوره 49 22 شماره
صفحات -
تاریخ انتشار 2013